The RNF168 paralog RNF169 defines a new class of ubiquitylated histone reader involved in the response to DNA damage

Site-specific histone ubiquitylation plays a central role in orchestrating the response to DNA double-strand breaks (DSBs). DSBs elicit a cascade of events controlled by the ubiquitin ligase RNF168, which promotes the accumulation of repair factors such as 53BP1 and BRCA1 on the chromatin flanking t...

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Udgivet i:eLife
Main Authors: Kitevski-LeBlanc, Julianne, Fradet-Turcotte, Amélie, Kukic, Predrag, Wilson, Marcus D, Portella, Guillem, Yuwen, Tairan, Panier, Stephanie, Duan, Shili, Canny, Marella D, van Ingen, Hugo, Arrowsmith, Cheryl H, Rubinstein, John L, Vendruscolo, Michele, Durocher, Daniel, Kay, Lewis E
Format: Artigo
Sprog:Inglês
Udgivet: eLife Sciences Publications, Ltd 2017
Fag:
Biophysics and Structural Biology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5426901/
https://ncbi.nlm.nih.gov/pubmed/28406400
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.23872
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