DNA damage-induced histone H1 ubiquitylation is mediated by HUWE1 and stimulates the RNF8-RNF168 pathway

The DNA damage response (DDR), comprising distinct repair and signalling pathways, safeguards genomic integrity. Protein ubiquitylation is an important regulatory mechanism of the DDR. To study its role in the UV-induced DDR, we characterized changes in protein ubiquitylation following DNA damage us...

Full description

Saved in:
Bibliographic Details
Published in:Sci Rep
Main Authors: Mandemaker, I. K., van Cuijk, L., Janssens, R. C., Lans, H., Bezstarosti, K., Hoeijmakers, J. H., Demmers, J. A., Vermeulen, W., Marteijn, J. A.
Format: Artigo
Language:Inglês
Published: Nature Publishing Group UK 2017
Subjects:
Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5681673/
https://ncbi.nlm.nih.gov/pubmed/29127375
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-15194-y
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items