RNF168 and USP10 regulate topoisomerase IIα function via opposing effects on its ubiquitylation

Topoisomerase IIα (TOP2α) is essential for chromosomal condensation and segregation, as well as genomic integrity. Here we report that RNF168, an E3 ligase mutated in the human RIDDLE syndrome, interacts with TOP2α and mediates its ubiquitylation. RNF168 deficiency impairs decatenation activity of T...

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Gepubliceerd in:Nat Commun
Hoofdauteurs: Guturi, Kiran Kumar Naidu, Bohgaki, Miyuki, Bohgaki, Toshiyuki, Srikumar, Tharan, Ng, Deborah, Kumareswaran, Ramya, El Ghamrasni, Samah, Jeon, Justin, Patel, Parasvi, Eldin, Mohamed Saad, Bristow, Rob, Cheung, Peter, Stewart, Grant S., Raught, Brian, Hakem, Anne, Hakem, Razqallah
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Nature Publishing Group 2016
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5007378/
https://ncbi.nlm.nih.gov/pubmed/27558965
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms12638
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