RNF168 regulates R-loop resolution and genomic stability in BRCA1/2-deficient tumors

Germline mutations in BRCA1 and BRCA2 (BRCA1/2) genes considerably increase breast and ovarian cancer risk. Given that tumors with these mutations have elevated genomic instability, they exhibit relative vulnerability to certain chemotherapies and targeted treatments based on poly (ADP-ribose) polym...

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Vydáno v:J Clin Invest
Hlavní autoři: Patel, Parasvi S., Abraham, Karan Joshua, Guturi, Kiran Kumar Naidu, Halaby, Marie-Jo, Khan, Zahra, Palomero, Luis, Ho, Brandon, Duan, Shili, St-Germain, Jonathan, Algouneh, Arash, Mateo, Francesca, El Ghamrasni, Samah, Barbour, Haithem, Barnes, Daniel R., Beesley, Jonathan, Sanchez, Otto, Berman, Hal K., Brown, Grant W., El Bachir Affar, Chenevix-Trench, Georgia, Antoniou, Antonis C., Arrowsmith, Cheryl H., Raught, Brian, Pujana, Miquel Angel, Mekhail, Karim, Hakem, Anne, Hakem, Razqallah
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Clinical Investigation 2021
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7843228/
https://ncbi.nlm.nih.gov/pubmed/33529165
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI140105
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