RNF168 regulates R-loop resolution and genomic stability in BRCA1/2-deficient tumors

Germline mutations in BRCA1 and BRCA2 (BRCA1/2) genes considerably increase breast and ovarian cancer risk. Given that tumors with these mutations have elevated genomic instability, they exhibit relative vulnerability to certain chemotherapies and targeted treatments based on poly (ADP-ribose) polym...

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Detalhes bibliográficos
Publicado no:J Clin Invest
Principais autores: Patel, Parasvi S., Abraham, Karan Joshua, Guturi, Kiran Kumar Naidu, Halaby, Marie-Jo, Khan, Zahra, Palomero, Luis, Ho, Brandon, Duan, Shili, St-Germain, Jonathan, Algouneh, Arash, Mateo, Francesca, El Ghamrasni, Samah, Barbour, Haithem, Barnes, Daniel R., Beesley, Jonathan, Sanchez, Otto, Berman, Hal K., Brown, Grant W., El Bachir Affar, Chenevix-Trench, Georgia, Antoniou, Antonis C., Arrowsmith, Cheryl H., Raught, Brian, Pujana, Miquel Angel, Mekhail, Karim, Hakem, Anne, Hakem, Razqallah
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2021
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7843228/
https://ncbi.nlm.nih.gov/pubmed/33529165
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI140105
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