RNF168 and USP10 regulate topoisomerase IIα function via opposing effects on its ubiquitylation

Topoisomerase IIα (TOP2α) is essential for chromosomal condensation and segregation, as well as genomic integrity. Here we report that RNF168, an E3 ligase mutated in the human RIDDLE syndrome, interacts with TOP2α and mediates its ubiquitylation. RNF168 deficiency impairs decatenation activity of T...

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Pubblicato in:Nat Commun
Autori principali: Guturi, Kiran Kumar Naidu, Bohgaki, Miyuki, Bohgaki, Toshiyuki, Srikumar, Tharan, Ng, Deborah, Kumareswaran, Ramya, El Ghamrasni, Samah, Jeon, Justin, Patel, Parasvi, Eldin, Mohamed Saad, Bristow, Rob, Cheung, Peter, Stewart, Grant S., Raught, Brian, Hakem, Anne, Hakem, Razqallah
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 2016
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5007378/
https://ncbi.nlm.nih.gov/pubmed/27558965
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms12638
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