RNF8- and RNF168-dependent degradation of KDM4A/JMJD2A triggers 53BP1 recruitment to DNA damage sites

In response to DNA damage, cells initiate complex signalling cascades leading to growth arrest and DNA repair. The recruitment of 53BP1 to damaged sites requires the activation of the ubiquitination cascade controlled by the E3 ubiquitin ligases RNF8 and RNF168, and methylation of histone H4 on lysi...

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Detalhes bibliográficos
Main Authors: Mallette, Frédérick A, Mattiroli, Francesca, Cui, Gaofeng, Young, Leah C, Hendzel, Michael J, Mer, Georges, Sixma, Titia K, Richard, Stéphane
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3343333/
https://ncbi.nlm.nih.gov/pubmed/22373579
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2012.47
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