RNF8- and RNF168-dependent degradation of KDM4A/JMJD2A triggers 53BP1 recruitment to DNA damage sites

In response to DNA damage, cells initiate complex signalling cascades leading to growth arrest and DNA repair. The recruitment of 53BP1 to damaged sites requires the activation of the ubiquitination cascade controlled by the E3 ubiquitin ligases RNF8 and RNF168, and methylation of histone H4 on lysi...

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Detaylı Bibliyografya
Asıl Yazarlar: Mallette, Frédérick A, Mattiroli, Francesca, Cui, Gaofeng, Young, Leah C, Hendzel, Michael J, Mer, Georges, Sixma, Titia K, Richard, Stéphane
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Nature Publishing Group 2012
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3343333/
https://ncbi.nlm.nih.gov/pubmed/22373579
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2012.47
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