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The nucleosome acidic patch plays a critical role in RNF168-dependent ubiquitination of histone H2A
During DNA damage response, the RING E3 ligase RNF168 ubiquitinates nucleosomal H2A at K13–15. Here we show that the ubiquitination reaction is regulated by its substrate. We define a region on the RING domain important for target recognition and identify the H2A/H2B dimer as the minimal substrate t...
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| Autores principales: | , , , , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
Nature Pub. Group
2014
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3929782/ https://ncbi.nlm.nih.gov/pubmed/24518117 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms4291 |
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