A viral E3 ligase targets RNF8 and RNF168 to control histone ubiquitination and DNA damage responses

The ICP0 protein of herpes simplex virus type 1 is an E3 ubiquitin ligase and transactivator required for the efficient switch between latent and lytic infection. As DNA damaging treatments are known to reactivate latent virus, we wished to explore whether ICP0 modulates the cellular response to DNA...

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Autors principals: Lilley, Caroline E, Chaurushiya, Mira S, Boutell, Chris, Landry, Sebastien, Suh, Junghae, Panier, Stephanie, Everett, Roger D, Stewart, Grant S, Durocher, Daniel, Weitzman, Matthew D
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2010
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2837166/
https://ncbi.nlm.nih.gov/pubmed/20075863
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2009.400
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