Orchestration of the DNA-damage response by the RNF8 ubiquitin ligase

Cells respond to DNA double-strand breaks (DSBs) by recruiting factors such as the DNA-damage mediator protein MDC1, p53-binding protein 1 (53BP1) and the breast cancer susceptibility protein BRCA1 to sites of damaged DNA. Here, we reveal that the ubiquitin ligase RNF8 mediates ubiquitin conjugation...

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Detalhes bibliográficos
Main Authors: Kolas, Nadine K., Chapman, J. Ross, Nakada, Shinichiro, Ylanko, Jarkko, Chahwan, Richard, Sweeney, Frédéric D., Panier, Stephanie, Mendez, Megan, Wildenhain, Jan, Thomson, Timothy M., Pelletier, Laurence, Jackson, Stephen P., Durocher, Daniel
Formato: Artigo
Idioma:Inglês
Publicado em: 2007
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2430610/
https://ncbi.nlm.nih.gov/pubmed/18006705
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1150034
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