Orchestration of the DNA-damage response by the RNF8 ubiquitin ligase

Cells respond to DNA double-strand breaks (DSBs) by recruiting factors such as the DNA-damage mediator protein MDC1, p53-binding protein 1 (53BP1) and the breast cancer susceptibility protein BRCA1 to sites of damaged DNA. Here, we reveal that the ubiquitin ligase RNF8 mediates ubiquitin conjugation...

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Hlavní autoři: Kolas, Nadine K., Chapman, J. Ross, Nakada, Shinichiro, Ylanko, Jarkko, Chahwan, Richard, Sweeney, Frédéric D., Panier, Stephanie, Mendez, Megan, Wildenhain, Jan, Thomson, Timothy M., Pelletier, Laurence, Jackson, Stephen P., Durocher, Daniel
Médium: Artigo
Jazyk:Inglês
Vydáno: 2007
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2430610/
https://ncbi.nlm.nih.gov/pubmed/18006705
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1150034
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