Structural basis of specific H2A K13/K15 ubiquitination by RNF168

Ubiquitination of chromatin by modification of histone H2A is a critical step in both regulation of DNA repair and regulation of cell fate. These very different outcomes depend on the selective modification of distinct lysine residues in H2A, each by a specific E3 ligase. While polycomb PRC1 complex...

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Udgivet i:Nat Commun
Main Authors: Horn, Velten, Uckelmann, Michael, Zhang, Heyi, Eerland, Jelmer, Aarsman, Ivette, le Paige, Ulric B., Davidovich, Chen, Sixma, Titia K., van Ingen, Hugo
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2019
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6465349/
https://ncbi.nlm.nih.gov/pubmed/30988309
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-09756-z
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