BRCA1 haploinsufficiency is masked by RNF168-mediated chromatin ubiquitylation

BRCA1 functions at two distinct steps during homologous recombination (HR). Initially, it promotes DNA end resection, and subsequently recruits the PALB2 and BRCA2 mediator complex, which stabilizes RAD51-DNA nucleoprotein filaments. Loss of 53BP1 rescues the HR defect in BRCA1 deficient cells by in...

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Pubblicato in:Mol Cell
Autori principali: Zong, Dali, Adam, Salomé, Wang, Yifan, Sasanuma, Hiroyuki, Callén, Elsa, Murga, Matilde, Day, Amanda, Kruhlak, Michael J., Wong, Nancy, Munro, Meagan, Chaudhuri, Arnab Ray, Karim, Baktiar, Xia, Bing, Takeda, Shunichi, Johnson, Neil, Durocher, Daniel, Nussenzweig, André
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2019
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6430682/
https://ncbi.nlm.nih.gov/pubmed/30704900
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2018.12.010
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