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Targeting unfolded protein response signaling pathways to ameliorate protein misfolding diseases
Protein homeostasis (or proteostasis) within the endoplasmic reticulum (ER) is regulated by the unfolded protein response (UPR). The UPR consists of three integrated signaling pathways activated by the accumulation of misfolded proteins within the ER lumen. Activation of the UPR alters ER proteostas...
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| 出版年: | Curr Opin Chem Biol |
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| 主要な著者: | , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2013
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5859939/ https://ncbi.nlm.nih.gov/pubmed/23647985 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cbpa.2013.04.009 |
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