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Targeting unfolded protein response signaling pathways to ameliorate protein misfolding diseases
Protein homeostasis (or proteostasis) within the endoplasmic reticulum (ER) is regulated by the unfolded protein response (UPR). The UPR consists of three integrated signaling pathways activated by the accumulation of misfolded proteins within the ER lumen. Activation of the UPR alters ER proteostas...
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| Publicado no: | Curr Opin Chem Biol |
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| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5859939/ https://ncbi.nlm.nih.gov/pubmed/23647985 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cbpa.2013.04.009 |
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