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Targeting unfolded protein response signaling pathways to ameliorate protein misfolding diseases

Protein homeostasis (or proteostasis) within the endoplasmic reticulum (ER) is regulated by the unfolded protein response (UPR). The UPR consists of three integrated signaling pathways activated by the accumulation of misfolded proteins within the ER lumen. Activation of the UPR alters ER proteostas...

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Detalles Bibliográficos
Publicado en:Curr Opin Chem Biol
Main Authors: Ryno, Lisa M, Wiseman, R Luke, Kelly, Jeffery W
Formato: Artigo
Idioma:Inglês
Publicado: 2013
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5859939/
https://ncbi.nlm.nih.gov/pubmed/23647985
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cbpa.2013.04.009
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