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Targeting unfolded protein response signaling pathways to ameliorate protein misfolding diseases
Protein homeostasis (or proteostasis) within the endoplasmic reticulum (ER) is regulated by the unfolded protein response (UPR). The UPR consists of three integrated signaling pathways activated by the accumulation of misfolded proteins within the ER lumen. Activation of the UPR alters ER proteostas...
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| Publié dans: | Curr Opin Chem Biol |
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| Auteurs principaux: | , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
2013
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5859939/ https://ncbi.nlm.nih.gov/pubmed/23647985 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cbpa.2013.04.009 |
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