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Targeting unfolded protein response signaling pathways to ameliorate protein misfolding diseases

Protein homeostasis (or proteostasis) within the endoplasmic reticulum (ER) is regulated by the unfolded protein response (UPR). The UPR consists of three integrated signaling pathways activated by the accumulation of misfolded proteins within the ER lumen. Activation of the UPR alters ER proteostas...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
में प्रकाशित:Curr Opin Chem Biol
मुख्य लेखकों: Ryno, Lisa M, Wiseman, R Luke, Kelly, Jeffery W
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: 2013
विषय:
ऑनलाइन पहुंच:https://ncbi.nlm.nih.gov/pmc/articles/PMC5859939/
https://ncbi.nlm.nih.gov/pubmed/23647985
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cbpa.2013.04.009
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