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The Tetrazole VT-1161 Is a Potent Inhibitor of Trichophyton rubrum through Its Inhibition of T. rubrum CYP51
Prior to characterization of antifungal inhibitors that target CYP51, Trichophyton rubrum CYP51 was expressed in Escherichia coli, purified, and characterized. T. rubrum CYP51 bound lanosterol, obtusifoliol, and eburicol with similar affinities (dissociation constant [K(d)] values, 22.7, 20.3, and 2...
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| Publicat a: | Antimicrob Agents Chemother |
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| Autors principals: | , , , , , , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
American Society for Microbiology
2017
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5487648/ https://ncbi.nlm.nih.gov/pubmed/28483956 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00333-17 |
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