Structural analyses of Candida albicans sterol 14α-demethylase complexed with azole drugs address the molecular basis of azole-mediated inhibition of fungal sterol biosynthesis

Por Hargrove, Tatiana Y., Friggeri, Laura, Wawrzak, Zdzislaw, Qi, Aidong, Hoekstra, William J., Schotzinger, Robert J., York, John D., Guengerich, F. Peter, Lepesheva, Galina I.
Publicado no J Biol Chem (2017)

VT-1161 Protects Immunosuppressed Mice from Rhizopus arrhizus var. arrhizus Infection

Por Gebremariam, Teclegiorgis, Wiederhold, Nathan P., Fothergill, Annette W., Garvey, Edward P., Hoekstra, William J., Schotzinger, Robert J., Patterson, Thomas F., Filler, Scott G., Ibrahim, Ashraf S.
Publicado no Antimicrob Agents Chemother (2015)

The Investigational Drug VT-1129 Is a Highly Potent Inhibitor of Cryptococcus Species CYP51 but Only Weakly Inhibits the Human Enzyme

Por Warrilow, Andrew G. S., Parker, Josie E., Price, Claire L., Nes, W. David, Garvey, Edward P., Hoekstra, William J., Schotzinger, Robert J., Kelly, Diane E., Kelly, Steven L.
Publicado no Antimicrob Agents Chemother (2016)

The Investigational Fungal Cyp51 Inhibitor VT-1129 Demonstrates Potent In Vitro Activity against Cryptococcus neoformans and Cryptococcus gattii

Por Lockhart, Shawn R., Fothergill, Annette W., Iqbal, Naureen, Bolden, Carol B., Grossman, Nina T., Garvey, Edward P., Brand, Stephen R., Hoekstra, William J., Schotzinger, Robert J., Ottinger, Elizabeth, Patterson, Thomas F., Wiederhold, Nathan P.
Publicado no Antimicrob Agents Chemother (2016)

Clinical Candidate VT-1161's Antiparasitic Effect In Vitro, Activity in a Murine Model of Chagas Disease, and Structural Characterization in Complex with the Target Enzyme CYP51 fr...

Por Hoekstra, William J., Hargrove, Tatiana Y., Wawrzak, Zdzislaw, da Gama Jaen Batista, Denise, da Silva, Cristiane F., Nefertiti, Aline S. G., Rachakonda, Girish, Schotzinger, Robert J., Villalta, Fernando, Soeiro, Maria de Nazaré C., Lepesheva, Galina I.
Publicado no Antimicrob Agents Chemother (2016)

Evaluation of VT-1161 for Treatment of Coccidioidomycosis in Murine Infection Models

Por Shubitz, Lisa F., Trinh, Hien T., Galgiani, John N., Lewis, Maria L., Fothergill, Annette W., Wiederhold, Nathan P., Barker, Bridget M., Lewis, Eric R. G., Doyle, Adina L., Hoekstra, William J., Schotzinger, Robert J., Garvey, Edward P.
Publicado no Antimicrob Agents Chemother (2015)