The Investigational Drug VT-1129 Is a Highly Potent Inhibitor of Cryptococcus Species CYP51 but Only Weakly Inhibits the Human Enzyme

Cryptococcosis is a life-threatening disease often associated with HIV infection. Three Cryptococcus species CYP51 enzymes were purified and catalyzed the 14α-demethylation of lanosterol, eburicol, and obtusifoliol. The investigational agent VT-1129 bound tightly to all three CYP51 proteins (dissoci...

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Xehetasun bibliografikoak
Argitaratua izan da:Antimicrob Agents Chemother
Egile Nagusiak: Warrilow, Andrew G. S., Parker, Josie E., Price, Claire L., Nes, W. David, Garvey, Edward P., Hoekstra, William J., Schotzinger, Robert J., Kelly, Diane E., Kelly, Steven L.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: American Society for Microbiology 2016
Gaiak:
Mechanisms of Action: Physiological Effects
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC4958158/
https://ncbi.nlm.nih.gov/pubmed/27161631
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00349-16
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