The Fungal Cyp51 Inhibitor VT-1129 Is Efficacious in an Experimental Model of Cryptococcal Meningitis

Cryptococcal meningitis is a significant cause of morbidity and mortality in immunocompromised patients. VT-1129 is a novel fungus-specific Cyp51 inhibitor with potent in vitro activity against Cryptococcus species. Our objective was to evaluate the in vivo efficacy of VT-1129 against cryptococcal m...

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Detalhes bibliográficos
Publicado no:Antimicrob Agents Chemother
Main Authors: Wiederhold, Nathan P., Najvar, Laura K., Garvey, Edward P., Brand, Stephen R., Xu, Xin, Ottinger, Elizabeth A., Alimardanov, Asaf, Cradock, Jim, Behnke, Mark, Hoekstra, William J., Schotzinger, Robert J., Jaramillo, Rosie, Olivo, Marcos, Kirkpatrick, William R., Patterson, Thomas F.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2018
Assuntos:
Experimental Therapeutics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6125545/
https://ncbi.nlm.nih.gov/pubmed/29987152
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01071-18
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