The Fungal Cyp51 Inhibitor VT-1129 Is Efficacious in an Experimental Model of Cryptococcal Meningitis

Cryptococcal meningitis is a significant cause of morbidity and mortality in immunocompromised patients. VT-1129 is a novel fungus-specific Cyp51 inhibitor with potent in vitro activity against Cryptococcus species. Our objective was to evaluate the in vivo efficacy of VT-1129 against cryptococcal m...

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Détails bibliographiques
Publié dans:Antimicrob Agents Chemother
Auteurs principaux: Wiederhold, Nathan P., Najvar, Laura K., Garvey, Edward P., Brand, Stephen R., Xu, Xin, Ottinger, Elizabeth A., Alimardanov, Asaf, Cradock, Jim, Behnke, Mark, Hoekstra, William J., Schotzinger, Robert J., Jaramillo, Rosie, Olivo, Marcos, Kirkpatrick, William R., Patterson, Thomas F.
Format: Artigo
Langue:Inglês
Publié: American Society for Microbiology 2018
Sujets:
Experimental Therapeutics
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6125545/
https://ncbi.nlm.nih.gov/pubmed/29987152
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01071-18
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