The Tetrazole VT-1161 Is a Potent Inhibitor of Trichophyton rubrum through Its Inhibition of T. rubrum CYP51

Prior to characterization of antifungal inhibitors that target CYP51, Trichophyton rubrum CYP51 was expressed in Escherichia coli, purified, and characterized. T. rubrum CYP51 bound lanosterol, obtusifoliol, and eburicol with similar affinities (dissociation constant [K(d)] values, 22.7, 20.3, and 2...

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Detalhes bibliográficos
Publicado no:Antimicrob Agents Chemother
Main Authors: Warrilow, Andrew G. S., Parker, Josie E., Price, Claire L., Garvey, Edward P., Hoekstra, William J., Schotzinger, Robert J., Wiederhold, Nathan P., Nes, W. David, Kelly, Diane E., Kelly, Steven L.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2017
Assuntos:
Experimental Therapeutics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5487648/
https://ncbi.nlm.nih.gov/pubmed/28483956
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00333-17
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