The Tetrazole VT-1161 Is a Potent Inhibitor of Trichophyton rubrum through Its Inhibition of T. rubrum CYP51

Prior to characterization of antifungal inhibitors that target CYP51, Trichophyton rubrum CYP51 was expressed in Escherichia coli, purified, and characterized. T. rubrum CYP51 bound lanosterol, obtusifoliol, and eburicol with similar affinities (dissociation constant [K(d)] values, 22.7, 20.3, and 2...

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Bibliografske podrobnosti
izdano v:Antimicrob Agents Chemother
Main Authors: Warrilow, Andrew G. S., Parker, Josie E., Price, Claire L., Garvey, Edward P., Hoekstra, William J., Schotzinger, Robert J., Wiederhold, Nathan P., Nes, W. David, Kelly, Diane E., Kelly, Steven L.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology 2017
Teme:
Experimental Therapeutics
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5487648/
https://ncbi.nlm.nih.gov/pubmed/28483956
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00333-17
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