The Tetrazole VT-1161 Is a Potent Inhibitor of Trichophyton rubrum through Its Inhibition of T. rubrum CYP51

Prior to characterization of antifungal inhibitors that target CYP51, Trichophyton rubrum CYP51 was expressed in Escherichia coli, purified, and characterized. T. rubrum CYP51 bound lanosterol, obtusifoliol, and eburicol with similar affinities (dissociation constant [K(d)] values, 22.7, 20.3, and 2...

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Vydáno v:Antimicrob Agents Chemother
Hlavní autoři: Warrilow, Andrew G. S., Parker, Josie E., Price, Claire L., Garvey, Edward P., Hoekstra, William J., Schotzinger, Robert J., Wiederhold, Nathan P., Nes, W. David, Kelly, Diane E., Kelly, Steven L.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 2017
Témata:
Experimental Therapeutics
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5487648/
https://ncbi.nlm.nih.gov/pubmed/28483956
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00333-17
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