Xist-dependent imprinted X inactivation and the early developmental consequences of its failure

The long non-coding RNA Xist is only expressed from the paternal X chromosome in mouse pre-implantation female embryos and leads to its transcriptional silencing. In females, absence of Xist leads to post-implantation lethality. Here we report that the initiation of imprinted XCI absolutely requires...

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Publié dans:Nat Struct Mol Biol
Auteurs principaux: Borensztein, Maud, Syx, Laurène, Ancelin, Katia, Diabangouaya, Patricia, Picard, Christel, Liu, Tao, Liang, Jun-Bin, Vassilev, Ivaylo, Galupa, Rafael, Servant, Nicolas, Barillot, Emmanuel, Surani, Azim, Chen, Chong-Jian, Heard, Edith
Format: Artigo
Langue:Inglês
Publié: 2017
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5337400/
https://ncbi.nlm.nih.gov/pubmed/28134930
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nsmb.3365
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