The role of Xist‐mediated Polycomb recruitment in the initiation of X‐chromosome inactivation

Xist RNA has been established as the master regulator of X‐chromosome inactivation (XCI) in female eutherian mammals, but its mechanism of action remains unclear. By creating novel Xist‐inducible mutants at the endogenous locus in male mouse embryonic stem (ES) cells, we dissect the role of the cons...

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Vydáno v:EMBO Rep
Hlavní autoři: Bousard, Aurélie, Raposo, Ana Cláudia, Żylicz, Jan Jakub, Picard, Christel, Pires, Vanessa Borges, Qi, Yanyan, Gil, Cláudia, Syx, Laurène, Chang, Howard Y, Heard, Edith, da Rocha, Simão Teixeira
Médium: Artigo
Jazyk:Inglês
Vydáno: John Wiley and Sons Inc. 2019
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6776897/
https://ncbi.nlm.nih.gov/pubmed/31456285
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embr.201948019
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