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The role of Xist‐mediated Polycomb recruitment in the initiation of X‐chromosome inactivation

Xist RNA has been established as the master regulator of X‐chromosome inactivation (XCI) in female eutherian mammals, but its mechanism of action remains unclear. By creating novel Xist‐inducible mutants at the endogenous locus in male mouse embryonic stem (ES) cells, we dissect the role of the cons...

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Publicado en:EMBO Rep
Autores principales: Bousard, Aurélie, Raposo, Ana Cláudia, Żylicz, Jan Jakub, Picard, Christel, Pires, Vanessa Borges, Qi, Yanyan, Gil, Cláudia, Syx, Laurène, Chang, Howard Y, Heard, Edith, da Rocha, Simão Teixeira
Formato: Artigo
Lenguaje:Inglês
Publicado: John Wiley and Sons Inc. 2019
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6776897/
https://ncbi.nlm.nih.gov/pubmed/31456285
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embr.201948019
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