The role of Xist‐mediated Polycomb recruitment in the initiation of X‐chromosome inactivation

Xist RNA has been established as the master regulator of X‐chromosome inactivation (XCI) in female eutherian mammals, but its mechanism of action remains unclear. By creating novel Xist‐inducible mutants at the endogenous locus in male mouse embryonic stem (ES) cells, we dissect the role of the cons...

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Pubblicato in:EMBO Rep
Autori principali: Bousard, Aurélie, Raposo, Ana Cláudia, Żylicz, Jan Jakub, Picard, Christel, Pires, Vanessa Borges, Qi, Yanyan, Gil, Cláudia, Syx, Laurène, Chang, Howard Y, Heard, Edith, da Rocha, Simão Teixeira
Natura: Artigo
Lingua:Inglês
Pubblicazione: John Wiley and Sons Inc. 2019
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Articles
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6776897/
https://ncbi.nlm.nih.gov/pubmed/31456285
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embr.201948019
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