Kinetics of Xist-induced gene silencing can be predicted from combinations of epigenetic and genomic features

To initiate X-Chromosome inactivation (XCI), the long noncoding RNA Xist mediates chromosome-wide gene silencing of one X Chromosome in female mammals to equalize gene dosage between the sexes. The efficiency of gene silencing is highly variable across genes, with some genes even escaping XCI in som...

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Salvato in:
Dettagli Bibliografici
Pubblicato in:Genome Res
Autori principali: Barros de Andrade e Sousa, Lisa, Jonkers, Iris, Syx, Laurène, Dunkel, Ilona, Chaumeil, Julie, Picard, Christel, Foret, Benjamin, Chen, Chong-Jian, Lis, John T., Heard, Edith, Schulz, Edda G., Marsico, Annalisa
Natura: Artigo
Lingua:Inglês
Pubblicazione: Cold Spring Harbor Laboratory Press 2019
Soggetti:
Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6633258/
https://ncbi.nlm.nih.gov/pubmed/31175153
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gr.245027.118
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