Kinetics of Xist-induced gene silencing can be predicted from combinations of epigenetic and genomic features

To initiate X-Chromosome inactivation (XCI), the long noncoding RNA Xist mediates chromosome-wide gene silencing of one X Chromosome in female mammals to equalize gene dosage between the sexes. The efficiency of gene silencing is highly variable across genes, with some genes even escaping XCI in som...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Genome Res
Prif Awduron: Barros de Andrade e Sousa, Lisa, Jonkers, Iris, Syx, Laurène, Dunkel, Ilona, Chaumeil, Julie, Picard, Christel, Foret, Benjamin, Chen, Chong-Jian, Lis, John T., Heard, Edith, Schulz, Edda G., Marsico, Annalisa
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Cold Spring Harbor Laboratory Press 2019
Pynciau:
Research
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC6633258/
https://ncbi.nlm.nih.gov/pubmed/31175153
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gr.245027.118
Tagiau: Ychwanegu Tag
Dim Tagiau, Byddwch y cyntaf i dagio'r cofnod hwn!

Eitemau Tebyg