A novel role for Xist RNA in the formation of a repressive nuclear compartment into which genes are recruited when silenced

During early mammalian female development, one of the two X chromosomes becomes inactivated. Although X-chromosome coating by Xist RNA is essential for the initiation of X inactivation, little is known about how this signal is transformed into transcriptional silencing. Here we show that exclusion o...

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Bibliographic Details
Main Authors: Chaumeil, Julie, Le Baccon, Patricia, Wutz, Anton, Heard, Edith
Format: Artigo
Language:Inglês
Published: Cold Spring Harbor Laboratory Press 2006
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Research Paper
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1553206/
https://ncbi.nlm.nih.gov/pubmed/16912274
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.380906
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