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Synergy of Eed and Tsix in the repression of Xist gene and X-chromosome inactivation

X-chromosome inactivation (XCI) depends on the noncoding Xist gene. Xist transcription is negatively regulated by its antisense partner Tsix, whose disruption results in nonrandom XCI in females. However, males can maintain Xist in a repressed state without Tsix, indicating participation of addition...

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Detalhes bibliográficos
Main Authors: Shibata, Shinwa, Yokota, Takashi, Wutz, Anton
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2008
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2486422/
https://ncbi.nlm.nih.gov/pubmed/18511907
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2008.110
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