Genetic and epigenetic features direct differential efficiency of Xist-mediated silencing at X-chromosomal and autosomal locations

Xist is indispensable for X chromosome inactivation. However, how Xist RNA directs chromosome-wide silencing and why some regions are more efficiently silenced than others remains unknown. Here, we explore the function of Xist by inducing ectopic Xist expression from multiple different X-linked and...

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Gepubliceerd in:Nat Commun
Hoofdauteurs: Loda, Agnese, Brandsma, Johannes H., Vassilev, Ivaylo, Servant, Nicolas, Loos, Friedemann, Amirnasr, Azadeh, Splinter, Erik, Barillot, Emmanuel, Poot, Raymond A., Heard, Edith, Gribnau, Joost
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Nature Publishing Group UK 2017
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5612955/
https://ncbi.nlm.nih.gov/pubmed/28947736
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-017-00528-1
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