Xist and Tsix Transcription Dynamics Is Regulated by the X-to-Autosome Ratio and Semistable Transcriptional States

In female mammals, X chromosome inactivation (XCI) is a key process in the control of gene dosage compensation between X-linked genes and autosomes. Xist and Tsix, two overlapping antisense-transcribed noncoding genes, are central elements of the X inactivation center (Xic) regulating XCI. Xist upre...

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Pubblicato in:Mol Cell Biol
Autori principali: Loos, Friedemann, Maduro, Cheryl, Loda, Agnese, Lehmann, Johannes, Kremers, Gert-Jan, ten Berge, Derk, Grootegoed, J. Anton, Gribnau, Joost
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 2016
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Articles
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5064214/
https://ncbi.nlm.nih.gov/pubmed/27528619
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00183-16
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