Efficiency of Xist-mediated silencing on autosomes is linked to chromosomal domain organisation

BACKGROUND: X chromosome inactivation, the mechanism used by mammals to equalise dosage of X-linked genes in XX females relative to XY males, is triggered by chromosome-wide localisation of a cis-acting non-coding RNA, Xist. The mechanism of Xist RNA spreading and Xist-dependent silencing is poorly...

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Main Authors: Tang, Y Amy, Huntley, Derek, Montana, Giovanni, Cerase, Andrea, Nesterova, Tatyana B, Brockdorff, Neil
Formato: Artigo
Idioma:Inglês
Publicado: BioMed Central 2010
Assuntos:
Research
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2873326/
https://ncbi.nlm.nih.gov/pubmed/20459652
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1756-8935-3-10
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