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Efficiency of Xist-mediated silencing on autosomes is linked to chromosomal domain organisation
BACKGROUND: X chromosome inactivation, the mechanism used by mammals to equalise dosage of X-linked genes in XX females relative to XY males, is triggered by chromosome-wide localisation of a cis-acting non-coding RNA, Xist. The mechanism of Xist RNA spreading and Xist-dependent silencing is poorly...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
BioMed Central
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2873326/ https://ncbi.nlm.nih.gov/pubmed/20459652 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1756-8935-3-10 |
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