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Advances in understanding chromosome silencing by the long non-coding RNA Xist

In female mammals, one of the two X chromosomes becomes genetically silenced to compensate for dosage imbalance of X-linked genes between XX females and XY males. X chromosome inactivation (X-inactivation) is a classical model for epigenetic gene regulation in mammals and has been studied for half a...

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Bibliografiske detaljer
Main Authors: Sado, Takashi, Brockdorff, Neil
Format: Artigo
Sprog:Inglês
Udgivet: The Royal Society 2013
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3539355/
https://ncbi.nlm.nih.gov/pubmed/23166390
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1098/rstb.2011.0325
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