hnRNPK Recruits PCGF3/5-PRC1 to the Xist RNA B-Repeat to Establish Polycomb-Mediated Chromosomal Silencing

The Polycomb-repressive complexes PRC1 and PRC2 play a key role in chromosome silencing induced by the non-coding RNA Xist. Polycomb recruitment is initiated by the PCGF3/5-PRC1 complex, which catalyzes chromosome-wide H2A lysine 119 ubiquitylation, signaling recruitment of other PRC1 complexes, and...

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Gepubliceerd in:Mol Cell
Hoofdauteurs: Pintacuda, Greta, Wei, Guifeng, Roustan, Chloë, Kirmizitas, Burcu Anil, Solcan, Nicolae, Cerase, Andrea, Castello, Alfredo, Mohammed, Shabaz, Moindrot, Benoît, Nesterova, Tatyana B., Brockdorff, Neil
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Cell Press 2017
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5735038/
https://ncbi.nlm.nih.gov/pubmed/29220657
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2017.11.013
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