Maternal LSD1/KDM1A is an essential regulator of chromatin and transcription landscapes during zygotic genome activation

Upon fertilization, the highly specialised sperm and oocyte genomes are remodelled to confer totipotency. The mechanisms of the dramatic reprogramming events that occur have remained unknown, and presumed roles of histone modifying enzymes are just starting to be elucidated. Here, we explore the fun...

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Vydáno v:eLife
Hlavní autoři: Ancelin, Katia, Syx, Laurène, Borensztein, Maud, Ranisavljevic, Noémie, Vassilev, Ivaylo, Briseño-Roa, Luis, Liu, Tao, Metzger, Eric, Servant, Nicolas, Barillot, Emmanuel, Chen, Chong-Jian, Schüle, Roland, Heard, Edith
Médium: Artigo
Jazyk:Inglês
Vydáno: eLife Sciences Publications, Ltd 2016
Témata:
Developmental Biology and Stem Cells
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4829419/
https://ncbi.nlm.nih.gov/pubmed/26836306
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.08851
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