Maternally provided LSD1/KDM1A enables the maternal-to-zygotic transition and prevents defects that manifest postnatally

Somatic cell nuclear transfer has established that the oocyte contains maternal factors with epigenetic reprogramming capacity. Yet the identity and function of these maternal factors during the gamete to embryo transition remains poorly understood. In C. elegans, LSD1/KDM1A enables this transition...

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Detalhes bibliográficos
Publicado no:eLife
Main Authors: Wasson, Jadiel A, Simon, Ashley K, Myrick, Dexter A, Wolf, Gernot, Driscoll, Shawn, Pfaff, Samuel L, Macfarlan, Todd S, Katz, David J
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications, Ltd 2016
Assuntos:
Developmental Biology and Stem Cells
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4829428/
https://ncbi.nlm.nih.gov/pubmed/26814574
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.08848
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