Endogenous retroviruses and neighboring genes are coordinately repressed by LSD1/KDM1A

Endogenous retroviruses (ERVs) constitute a substantial portion of mammalian genomes, and their retrotransposition activity helped to drive genetic variation, yet their expression is tightly regulated to prevent unchecked amplification. We generated a series of mouse mutants and embryonic stem (ES)...

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Main Authors: Macfarlan, Todd S., Gifford, Wesley D., Agarwal, Saurabh, Driscoll, Shawn, Lettieri, Karen, Wang, Jianxun, Andrews, Shane E., Franco, Laura, Rosenfeld, Michael G., Ren, Bing, Pfaff, Samuel L.
Formato: Artigo
Idioma:Inglês
Publicado: Cold Spring Harbor Laboratory Press 2011
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Research Paper
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3059833/
https://ncbi.nlm.nih.gov/pubmed/21357675
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.2008511
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