Maternally provided LSD1/KDM1A enables the maternal-to-zygotic transition and prevents defects that manifest postnatally

Somatic cell nuclear transfer has established that the oocyte contains maternal factors with epigenetic reprogramming capacity. Yet the identity and function of these maternal factors during the gamete to embryo transition remains poorly understood. In C. elegans, LSD1/KDM1A enables this transition...

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Publicat a:eLife
Autors principals: Wasson, Jadiel A, Simon, Ashley K, Myrick, Dexter A, Wolf, Gernot, Driscoll, Shawn, Pfaff, Samuel L, Macfarlan, Todd S, Katz, David J
Format: Artigo
Idioma:Inglês
Publicat: eLife Sciences Publications, Ltd 2016
Matèries:
Developmental Biology and Stem Cells
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4829428/
https://ncbi.nlm.nih.gov/pubmed/26814574
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.08848
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