The small molecule IMR-1 inhibits the Notch transcriptional activation complex to suppress tumorigenesis

In many cancers, aberrant Notch activity has been demonstrated to play a role in the initiation and maintenance of the neoplastic phenotype and in cancer stem cells, which may allude to its additional involvement in metastasis and resistance to therapy. Therefore, Notch is an exceedingly attractive...

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Publicat a:Cancer Res
Autors principals: Astudillo, Luisana, Da Silva, Thiago G., Wang, Zhiqiang, Han, Xiaoqing, Jin, Ke, VanWye, Jeffrey, Zhu, Xiaoxia, Weaver, Kelly, Oashi, Taiji, Lopes, Pedro E.M., Orton, Darren, Neitzel, Leif R., Lee, Ethan, Landgraf, Ralf, Robbins, David J, MacKerell, Alexander D., Capobianco, Anthony J.
Format: Artigo
Idioma:Inglês
Publicat: 2016
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4911243/
https://ncbi.nlm.nih.gov/pubmed/27197169
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-16-0061
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