Identification of a Paralog-Specific Notch1 Intracellular Domain Degron

Upon Notch pathway activation, the receptor is cleaved to release the Notch intracellular domain (NICD), which translocates to the nucleus to activate gene transcription. Using Xenopus egg extracts, we have identified a Notch1-specific destruction signal (N1-Box). We show that mutations in the N1-Bo...

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Detaylı Bibliyografya
Yayımlandı:Cell Rep
Asıl Yazarlar: Broadus, Matthew R., Chen, Tony W., Neitzel, Leif R., Ng, Victoria H., Jodoin, Jeanne N., Lee, Laura A., Salic, Adrian, Robbins, David J., Capobianco, Anthony J., Patton, James G., Huppert, Stacey S., Lee, Ethan
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2016
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4889555/
https://ncbi.nlm.nih.gov/pubmed/27210761
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2016.04.070
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