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Identification of a Paralog-Specific Notch1 Intracellular Domain Degron
Upon Notch pathway activation, the receptor is cleaved to release the Notch intracellular domain (NICD), which translocates to the nucleus to activate gene transcription. Using Xenopus egg extracts, we have identified a Notch1-specific destruction signal (N1-Box). We show that mutations in the N1-Bo...
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| Publicado no: | Cell Rep |
|---|---|
| Main Authors: | , , , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4889555/ https://ncbi.nlm.nih.gov/pubmed/27210761 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2016.04.070 |
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