The small molecule IMR-1 inhibits the Notch transcriptional activation complex to suppress tumorigenesis

In many cancers, aberrant Notch activity has been demonstrated to play a role in the initiation and maintenance of the neoplastic phenotype and in cancer stem cells, which may allude to its additional involvement in metastasis and resistance to therapy. Therefore, Notch is an exceedingly attractive...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Cancer Res
Egile Nagusiak: Astudillo, Luisana, Da Silva, Thiago G., Wang, Zhiqiang, Han, Xiaoqing, Jin, Ke, VanWye, Jeffrey, Zhu, Xiaoxia, Weaver, Kelly, Oashi, Taiji, Lopes, Pedro E.M., Orton, Darren, Neitzel, Leif R., Lee, Ethan, Landgraf, Ralf, Robbins, David J, MacKerell, Alexander D., Capobianco, Anthony J.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2016
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC4911243/
https://ncbi.nlm.nih.gov/pubmed/27197169
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-16-0061
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