The small molecule IMR-1 inhibits the Notch transcriptional activation complex to suppress tumorigenesis

In many cancers, aberrant Notch activity has been demonstrated to play a role in the initiation and maintenance of the neoplastic phenotype and in cancer stem cells, which may allude to its additional involvement in metastasis and resistance to therapy. Therefore, Notch is an exceedingly attractive...

Πλήρης περιγραφή

Αποθηκεύτηκε σε:
Λεπτομέρειες βιβλιογραφικής εγγραφής
Τόπος έκδοσης:Cancer Res
Κύριοι συγγραφείς: Astudillo, Luisana, Da Silva, Thiago G., Wang, Zhiqiang, Han, Xiaoqing, Jin, Ke, VanWye, Jeffrey, Zhu, Xiaoxia, Weaver, Kelly, Oashi, Taiji, Lopes, Pedro E.M., Orton, Darren, Neitzel, Leif R., Lee, Ethan, Landgraf, Ralf, Robbins, David J, MacKerell, Alexander D., Capobianco, Anthony J.
Μορφή: Artigo
Γλώσσα:Inglês
Έκδοση: 2016
Θέματα:
Article
Διαθέσιμο Online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4911243/
https://ncbi.nlm.nih.gov/pubmed/27197169
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-16-0061
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