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Automated selection of compounds with physicochemical properties to maximize bioavailability and druglikeness
Adequate bioavailability is one of the essential properties for an orally administered drug. Lipinski and others have formulated simplified rules in which compounds that satisfy selected physiochemical properties, for example, molecular weight (MW)≤500, or logarithm of octanol-water partition coeffi...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2010
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3160130/ https://ncbi.nlm.nih.gov/pubmed/21142079 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ci100359a |
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