Protein methionine oxidation augments reperfusion injury in acute ischemic stroke

Reperfusion injury can exacerbate tissue damage in ischemic stroke, but little is known about the mechanisms linking ROS to stroke severity. Here, we tested the hypothesis that protein methionine oxidation potentiates NF-κB activation and contributes to cerebral ischemia/reperfusion injury. We found...

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Detalhes bibliográficos
Publicado no:JCI Insight
Main Authors: Gu, Sean X., Blokhin, Ilya O., Wilson, Katina M., Dhanesha, Nirav, Doddapattar, Prakash, Grumbach, Isabella M., Chauhan, Anil K., Lentz, Steven R.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2016
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4902298/
https://ncbi.nlm.nih.gov/pubmed/27294204
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.86460
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