Protein methionine oxidation augments reperfusion injury in acute ischemic stroke

Reperfusion injury can exacerbate tissue damage in ischemic stroke, but little is known about the mechanisms linking ROS to stroke severity. Here, we tested the hypothesis that protein methionine oxidation potentiates NF-κB activation and contributes to cerebral ischemia/reperfusion injury. We found...

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Détails bibliographiques
Publié dans:JCI Insight
Auteurs principaux: Gu, Sean X., Blokhin, Ilya O., Wilson, Katina M., Dhanesha, Nirav, Doddapattar, Prakash, Grumbach, Isabella M., Chauhan, Anil K., Lentz, Steven R.
Format: Artigo
Langue:Inglês
Publié: American Society for Clinical Investigation 2016
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4902298/
https://ncbi.nlm.nih.gov/pubmed/27294204
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.86460
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