Endothelial cell-derived VWF is the major determinant that mediates VWF-dependent acute ischemic stroke by promoting post-ischemic thrombo-inflammation

OBJECTIVE: Von Willebrand factor (VWF), which is synthesized in endothelial cells and megakaryocytes, is known to worsen stroke outcome. In vitro studies suggest that platelet-derived VWF is biochemically different from the endothelial cell-derived VWF. However, little is known about relative contri...

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Опубликовано в: :Arterioscler Thromb Vasc Biol
Главные авторы: Dhanesha, Nirav, Prakash, Prem, Doddapattar, Prakash, Khanna, Ira, Pollpeter, Molly J, Nayak, Manasa K., Staber, Janice M., Chauhan, Anil K.
Формат: Artigo
Язык:Inglês
Опубликовано: 2016
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC5001895/
https://ncbi.nlm.nih.gov/pubmed/27444201
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/ATVBAHA.116.307660
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