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Genetic Ablation of Extra Domain A of Fibronectin in Hypercholesterolemic Mice Improves Stroke Outcome by Reducing Thrombo-Inflammation

BACKGROUND: The fibronectin splicing variant containing extra domain A (Fn-EDA) is present in negligible amounts in the plasma of healthy humans, but markedly elevated in patients with comorbid conditions including diabetes and hypercholesterolemia, which are risk factors for stroke. It remains unkn...

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Detalhes bibliográficos
Publicado no:Circulation
Main Authors: Dhanesha, Nirav, Ahmad, Ajmal, Prakash, Prem, Doddapattar, Prakash, Lentz, Steven R., Chauhan, Anil K.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4674336/
https://ncbi.nlm.nih.gov/pubmed/26508731
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCULATIONAHA.115.016540
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