Fibronectin splicing variants containing extra domain A promote atherosclerosis in mice through Toll-like receptor 4

OBJECTIVE: Cellular fibronectin containing extra domain A (EDA(+)-FN) is abundant in the arteries of patients with atherosclerosis. Several in vitro studies suggest that EDA(+)-FN interacts with Toll-like receptor 4 (TLR4). We tested the hypothesis that EDA(+)-FN exacerbates atherosclerosis through...

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Publié dans:Arterioscler Thromb Vasc Biol
Auteurs principaux: Doddapattar, Prakash, Gandhi, Chintan, Prakash, Prem, Dhanesha, Nirav, Grumbach, Isabella M., Dailey, Michael E., Lentz, Steven R., Chauhan, Anil K.
Format: Artigo
Langue:Inglês
Publié: 2015
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4618710/
https://ncbi.nlm.nih.gov/pubmed/26427793
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/ATVBAHA.115.306474
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